منابع مشابه
Population pharmacokinetics of exenatide
AIM The aim of the present analysis was to develop a core population pharmacokinetic model for the pharmacokinetic properties of immediate-release (IR) exenatide, which can be used in subsequent analyses of novel sustained-release formulations. METHODS Data from eight clinical trials, evaluating a wide range of doses and different administration routes, were available for analysis. All modell...
متن کاملPopulation pharmacokinetics of omeprazole in a random Iranian population
Background: Omeprazole is metabolized predominantly by CYP2C19, a polymorphically expressed enzymes that show marked interindividual and interethnic variation. These variations cause a substantial differences that have been reported in the pharmacokinetics of omeprazole. The aim of the present study was to evaluate the pharmacokinetic parameters of omeprazole in a random Iranian population. Met...
متن کاملEffect of renal impairment on the pharmacokinetics of exenatide
AIMS To evaluate the pharmacokinetics (PK), safety and tolerability of a single exenatide dose in patients with renal impairment (RI). METHODS Exenatide (5 or 10 microg) was injected subcutaneously in 31 subjects (one with Type 2 diabetes) stratified by renal function [Cockcroft-Gault creatinine clearance (CrCL), number of subjects]: normal (>80 ml min(-1), n = 8), mild RI (51-80 ml min(-1), ...
متن کاملpopulation pharmacokinetics of omeprazole in a random iranian population
background: omeprazole is metabolized predominantly by cyp2c19, a polymorphically expressed enzymes that show marked interindividual and interethnic variation. these variations cause a substantial differences that have been reported in the pharmacokinetics of omeprazole. the aim of the present study was to evaluate the pharmacokinetic parameters of omeprazole in a random iranian population. met...
متن کاملPopulation Pharmacokinetics of Pomalidomide
A population pharmacokinetic (PPK) model of pomalidomide was developed and the influence of demographic and disease-related covariates on PPK parameters was assessed based on data from 6 clinical trials of pomalidomide (dose range, 0.5-10 mg) in healthy participants (n = 96) and patients with multiple myeloma (MM; n = 144). PPK data described herein suggest that systemic clearance of pomalidomi...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2016
ISSN: 0306-5251
DOI: 10.1111/bcp.13135